Geometry nodes: Binormals & cross products
Cross Products
We can sample the tangent (forwards) and normal (outwards) vectors at a point on a curve. Those are orthogonal to one another but since we're in 3D space there must be a third 'direction' too. That's the binormal1!
Given any 2 vectors and we can find a third which is orthogonal to the plane the first two form by taking the cross product:
Binormal of a point on a curve
The binormal is therefore just the cross of the tangent and normal. And it takes just one node to calculate it: A Vector Math node.

Or in other words.
The operation can also be done on the left side of the sample node too, which could be handy if you'll feed the calculation to some other operation too:

Note the attribute type is set to Vector.
I've seen bitangent too, in the context of sampling a surface.↩